Interferons in hematopoiesis and leukemia
نویسندگان
چکیده
Interferons not only exert a fundamental role during inflammation and immune responses but also modulate the activity of hematopoietic stem cells during homeostatic and demand-adapted hematopoiesis. Identical mechanisms regulate the homeostasis and proliferation of leukemic stem cells (LSCs). Understanding these mechanisms may lead to novel therapeutic approaches against leukemia.
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I . Rigby WFC, Ball ED, Guyre PM, Fanger MV: The effects of recombinant-DNA-derived interferons on the growth of myeloid progenitor cells. Blood 65:858, 1985 2. Taetle R, Buick RM, McCulloch EA: Effect of interferon in vitro on colony formation in culture by blast cell progenitors in acute myeloblastic leukemia. Blood 56:549, 1980 3. Greenberg PL, Mosney SA: Cytotoxic effects of interferon in v...
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عنوان ژورنال:
دوره 2 شماره
صفحات -
تاریخ انتشار 2013